Available immediately, we have an NIH-funded Postdoctoral or Research Assistant position available to develop novel caging chemistries for in vivo drug uncaging. We develop photopharmacological tools to support our physiological studies into the neurochemical signaling mechanisms of pain modulation. We recently established caged opioid drugs that can be photoreleased in the mouse brain with UV light (manuscripts in review and in preparation). Based on this progress we have acquired new funding from the NIH Brain Initiative to expand this approach to other drugs and to include new caging chemistries optimized for in vivo applications.
Primary responsibilities include the design, synthesis and chemical characterization of new molecules. The position will also provide the opportunity to be trained in cell culture, transfection, and analysis of ligand activity at GPCRs using a plate reader, although this is not required.
Candidates must have extensive experience in synthetic organic chemistry. Training in the multistep synthesis of natural products, or in synthesis of probes for chemical biology applications is highly desired. Any biology experience would be a bonus. Applicants should hold a Ph.D. or equivalent degree in chemistry.
The Banghart Lab is located in the Center for Neural Circuits and Behavior (CNCB), which is the hub of UCSD Neuroscience community. We are proud to work in a highly interactive research environment that embraces diversity and work-life balance in addition to scientific excellence. The position will offer opportunities to write grants, train students and present findings at professional conferences. Salary and benefits will be commensurate with experience in accordance with UCSD guidelines. Funds to partially offset relocation costs are available.