Preprints
In vivo photopharmacology with light-activated opioid drugs
McClain SP*, Ma X*, Johnson DA, Johnson CA, Layden AE, Yung JC, Lubejko ST, Livrizzi G, He XJ, Zhou J, Ventriglia E, Rizzo A, Levinstein M, Gomez JL, Bonaventura J, Michaelides M, Banghart MR.
bioRxiv 2023.02.02.526901; doi: 10.1101/2023.02.02.526901
Articles
Layden AE*, Ma X*, Johnson CA, He XJ, Bucynski S, Banghart MR. A biomimetic C-terminal extension strategy for photocaging amidated neuropeptides. Journal of the American Chemical Society, Journal of the American Chemical Society (ASAP). doi: 10.1021/jacs.3c03913
Welsch L, Colantonio E, Frison M, Johnson DA, McClain SP, Mathis V, Banghart MR, Ben Hamida S, Darcq E, Kieffer BL. Mu Opioid Receptor-Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors. Biological Psychiatry (2023), June 5:S0006-3223(23)01328-8. doi: 10.1016/j.biopsych.2023.05.019.
Ma X*, Johnson DA*, He XJ, Layden, AE, McClain SP, Yung JC, Rizzo A, Bonaventura J, Banghart MR. In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior. Nature Methods (2023), 20(5): 682-685. doi: 10.1038/s41592-023-01819-w
See also a Research Briefing on this manuscript: Deep-brain photoactivation of an opioid peptide shapes mouse behavior within seconds. Nat Methods (2023). doi: 10.1038/s41592-023-01821-2
Lubejko ST, Graham RD, Livrizzi G, Schaefer R, Banghart MR, Creed MC. The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia. Frontiers in Systems Neuroscience (2022); 16:1044686 doi: 10.3389/fnsys.2022.1044686
He XJ, Patel J, Weiss CE, Ma X, Bloodgood BL, Banghart MR. Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons. eLife (2021); 10:e69746 doi: 10.7554/eLife.69746
He, XJ and Banghart MR. It’s lights out for presynaptic terminals. Neuron (2021), 109(11), p1755-57.
Liu, S., Kim, D., Oh, T.G., Pao, G.M.M., Kim, J., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M. and Han, S., “Neural basis of opioid-induced respiratory depression and its rescue,” Proceedings of the National Academy of Sciences (2021), June 8, 118(23):e2022134118. doi: 10.1073/pnas.2022134118.
Gutnick A, Banghart MR, West ER, Schwarz TL. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nature Cell Biology (2019), May 6. doi: 10.1038/s41556-019-0317-2.
Banghart MR*, He XJ, Sabatini, BL*. A Caged Enkephalin Optimized for Simultaneously Probing Mu and
Delta Opioid Receptors. ACS Chemical Neuroscience (2018), 9(4), 684-690.
Otopalik AG, Sutton AC, Banghart M, Marder E. When complex neuronal structures may not matter. Elife (2017), pii: e23508.
Banghart MR*, Neufeld SQ*, Mulder N, Sabatini BL. Enkephalin disinhibits mu-receptor rich striatal patches via delta opioid receptors. Neuron (2015), 88(6), 1227-39.
Olson J*, Banghart MR*, Sabatini BL, Ellis-Davies GCR. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. Journal of the American Chemical Society (2013), 135(42), 15948-54.
Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Molecular Pharmacology (2013), 84(5), 687-95.
Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron (2012), 73, 249-59.
Tochitsky I*, Banghart MR*, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D. Optical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nature Chemistry (2012), 4(2), 105-11.
Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FME, Stein M, Kramer RH, Trauner D. Tuning photochromic ion channel blockers. ACS Chemical Neuroscience (2011), 2(9), 536-543.
Fortin DL, Dunn TW, Fedorchak A, Allen D, Montpetit R, Banghart MR, Trauner D, Adelman JP, Kramer RH. Optogenetic photochemical control of designer K+ channels in mammalian neurons. Journal of Neurophysiology (2011), 106(1), 488-496.
Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Letters (2010), 10 (1), 250-254.
Banghart MR*, Mourot A*, Fortin DL, Yao JZ, Kramer RH, Trauner D. Photochromic blockers of voltage-gated potassium channels. Angewandte Chemie International Edition (2009), 48 (48), 9097-9101.
Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Photochemical control of endogenous ion channels and cellular excitability. Nature Methods (2008), 5(4), 331-338.
Banghart MR, Volgraf M, Trauner D. Engineering light gated ion channels. Biochemistry (2006), 45(51), 15129-15141.
Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K+ channel and a molecular photoswitch. Journal of Neurophysiology (2006), 96(5), 2792-2796.
Banghart M*, Borges K*, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience (2004), 7(12), 1381-1386.
Ren H, Grady S, Banghart M, Moulthrop JS, Kendrick H, Yardley V, Croft SL, Moyna G. Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European Journal of Medicinal Chemistry (2003), 38(11-12), 949-957.
Miller AK, Banghart MR, Beaudry CM, Suh JM, Trauner D. Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones. Tetrahedron (2003), 59(45), 8919-8930.
Banghart M, Grady S, Ren H, Freyer AI, Moyna G. Assignment of the 1H- and 13C-NMR spectra of purpurogallin derivatives and revision of the structure of purpurogallin tri-methylether using DPFGSE-NOE spectroscopy. Journal of Undergraduate Chemistry Research (2002), 1(2), 77-82.
Non-peer reviewed articles and book chapters
Banghart MR, Trauner D. A 1H NMR assay for quantifying the wavelength sensitivity of azobenzene-based photoswitchable ligands. In Methods in Molecular Biology: Chemical Neurobiology; Banghart MR, Ed.; Springer, New York, 2013; Vol. 995, pp 107.
Volgraf M, Banghart MR, Trauner D. Switchable proteins and channels. In Molecular Switches; Feringa BL, Browne WR, Eds.; Wiley-VCH, New York, 2011; Vol. 1, pp 563.
Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The American Association of Pharmaceutical Scientists Journal (2009) 11(1), 167-177.
In vivo photopharmacology with light-activated opioid drugs
McClain SP*, Ma X*, Johnson DA, Johnson CA, Layden AE, Yung JC, Lubejko ST, Livrizzi G, He XJ, Zhou J, Ventriglia E, Rizzo A, Levinstein M, Gomez JL, Bonaventura J, Michaelides M, Banghart MR.
bioRxiv 2023.02.02.526901; doi: 10.1101/2023.02.02.526901
Articles
Layden AE*, Ma X*, Johnson CA, He XJ, Bucynski S, Banghart MR. A biomimetic C-terminal extension strategy for photocaging amidated neuropeptides. Journal of the American Chemical Society, Journal of the American Chemical Society (ASAP). doi: 10.1021/jacs.3c03913
Welsch L, Colantonio E, Frison M, Johnson DA, McClain SP, Mathis V, Banghart MR, Ben Hamida S, Darcq E, Kieffer BL. Mu Opioid Receptor-Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors. Biological Psychiatry (2023), June 5:S0006-3223(23)01328-8. doi: 10.1016/j.biopsych.2023.05.019.
Ma X*, Johnson DA*, He XJ, Layden, AE, McClain SP, Yung JC, Rizzo A, Bonaventura J, Banghart MR. In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior. Nature Methods (2023), 20(5): 682-685. doi: 10.1038/s41592-023-01819-w
See also a Research Briefing on this manuscript: Deep-brain photoactivation of an opioid peptide shapes mouse behavior within seconds. Nat Methods (2023). doi: 10.1038/s41592-023-01821-2
Lubejko ST, Graham RD, Livrizzi G, Schaefer R, Banghart MR, Creed MC. The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia. Frontiers in Systems Neuroscience (2022); 16:1044686 doi: 10.3389/fnsys.2022.1044686
He XJ, Patel J, Weiss CE, Ma X, Bloodgood BL, Banghart MR. Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons. eLife (2021); 10:e69746 doi: 10.7554/eLife.69746
He, XJ and Banghart MR. It’s lights out for presynaptic terminals. Neuron (2021), 109(11), p1755-57.
Liu, S., Kim, D., Oh, T.G., Pao, G.M.M., Kim, J., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M. and Han, S., “Neural basis of opioid-induced respiratory depression and its rescue,” Proceedings of the National Academy of Sciences (2021), June 8, 118(23):e2022134118. doi: 10.1073/pnas.2022134118.
Gutnick A, Banghart MR, West ER, Schwarz TL. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nature Cell Biology (2019), May 6. doi: 10.1038/s41556-019-0317-2.
Banghart MR*, He XJ, Sabatini, BL*. A Caged Enkephalin Optimized for Simultaneously Probing Mu and
Delta Opioid Receptors. ACS Chemical Neuroscience (2018), 9(4), 684-690.
Otopalik AG, Sutton AC, Banghart M, Marder E. When complex neuronal structures may not matter. Elife (2017), pii: e23508.
Banghart MR*, Neufeld SQ*, Mulder N, Sabatini BL. Enkephalin disinhibits mu-receptor rich striatal patches via delta opioid receptors. Neuron (2015), 88(6), 1227-39.
Olson J*, Banghart MR*, Sabatini BL, Ellis-Davies GCR. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. Journal of the American Chemical Society (2013), 135(42), 15948-54.
Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Molecular Pharmacology (2013), 84(5), 687-95.
Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron (2012), 73, 249-59.
Tochitsky I*, Banghart MR*, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D. Optical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nature Chemistry (2012), 4(2), 105-11.
Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FME, Stein M, Kramer RH, Trauner D. Tuning photochromic ion channel blockers. ACS Chemical Neuroscience (2011), 2(9), 536-543.
Fortin DL, Dunn TW, Fedorchak A, Allen D, Montpetit R, Banghart MR, Trauner D, Adelman JP, Kramer RH. Optogenetic photochemical control of designer K+ channels in mammalian neurons. Journal of Neurophysiology (2011), 106(1), 488-496.
Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Letters (2010), 10 (1), 250-254.
Banghart MR*, Mourot A*, Fortin DL, Yao JZ, Kramer RH, Trauner D. Photochromic blockers of voltage-gated potassium channels. Angewandte Chemie International Edition (2009), 48 (48), 9097-9101.
Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Photochemical control of endogenous ion channels and cellular excitability. Nature Methods (2008), 5(4), 331-338.
Banghart MR, Volgraf M, Trauner D. Engineering light gated ion channels. Biochemistry (2006), 45(51), 15129-15141.
Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K+ channel and a molecular photoswitch. Journal of Neurophysiology (2006), 96(5), 2792-2796.
Banghart M*, Borges K*, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience (2004), 7(12), 1381-1386.
Ren H, Grady S, Banghart M, Moulthrop JS, Kendrick H, Yardley V, Croft SL, Moyna G. Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European Journal of Medicinal Chemistry (2003), 38(11-12), 949-957.
Miller AK, Banghart MR, Beaudry CM, Suh JM, Trauner D. Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones. Tetrahedron (2003), 59(45), 8919-8930.
Banghart M, Grady S, Ren H, Freyer AI, Moyna G. Assignment of the 1H- and 13C-NMR spectra of purpurogallin derivatives and revision of the structure of purpurogallin tri-methylether using DPFGSE-NOE spectroscopy. Journal of Undergraduate Chemistry Research (2002), 1(2), 77-82.
Non-peer reviewed articles and book chapters
Banghart MR, Trauner D. A 1H NMR assay for quantifying the wavelength sensitivity of azobenzene-based photoswitchable ligands. In Methods in Molecular Biology: Chemical Neurobiology; Banghart MR, Ed.; Springer, New York, 2013; Vol. 995, pp 107.
Volgraf M, Banghart MR, Trauner D. Switchable proteins and channels. In Molecular Switches; Feringa BL, Browne WR, Eds.; Wiley-VCH, New York, 2011; Vol. 1, pp 563.
Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The American Association of Pharmaceutical Scientists Journal (2009) 11(1), 167-177.