Preprints
Top-down control of the descending pain modulatory system drives placebo analgesia. Livrizzi G, Liao J, Johnson DA, Lubejko ST, Chang-Weinberg J, Dong C, Tian L, Banghart MR. bioRxiv [Preprint]. 2025 Feb 16:2025.02.13.638185. doi: 10.1101/2025.02.13.638185
Mimicking opioid analgesia in cortical pain circuits. James JG, McCall NM, Hsu AI, Oswell CS, Salimando GJ, Mahmood M, Wooldridge LM, Wachira M, Jo A, Sandoval Ortega RA, Wojick JA, Beattie K, Farinas SA, Chehimi SN, Rodrigues A, Ejoh LL, Kimmey BA, Lo E, Azouz G, Vasquez JJ, Banghart MR, Creasy KT, Beier KT, Ramakrishnan C, Crist RC, Reiner BC, Deisseroth K, Yttri EA, Corder G. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591113. doi: 10.1101/2024.04.26.591113.
Articles
A Chemically Stable Photocaged Noradrenaline. Buczynski SA, Li A, Chang-Weinberg J, Nawsheen SS, Banghart MR. ACS Chemical Neuroscience. 2025 Aug 6;16(15):2935-2944. doi: 10.1021/acschemneuro.5c00241
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR†, Banghart MR†, Tian L†. Nature Neuroscience. 2024 Sep;27(9) doi: 10.1038/s41593-024-01697-1.
Convergent inputs to the locus coeruleus from the ventrolateral periaqueductal gray and rostroventromedial medulla shape opioid-mediated descending pain modulation. Lubejko ST, Livrizzi G, Buczynski SA, Patel J, Yung JC, Yaksh TL, Banghart MR. Science Advances (2024), 26 Apr 2024, Vol 10, Issue 17. doi: 10.1126/sciadv.adj958
In vivo photopharmacology with light-activated opioid drugs. McClain SP*, Ma X*, Johnson DA, Johnson CA, Layden AE, Yung JC, Lubejko ST, Livrizzi G, He XJ, Zhou J, Ventriglia E, Rizzo A, Levinstein M, Gomez JL, Bonaventura J, Michaelides M, Banghart MR. Neuron (2023), Dec 20; 111(24):3926-3940.e10. doi: 10.1016/j.neuron.2023.09.017. Epub 2023 Oct 16.
A biomimetic C-terminal extension strategy for photocaging amidated neuropeptides. Layden AE*, Ma X*, Johnson CA, He XJ, Bucynski S, Banghart MR. Journal of the American Chemical Society (2023) Sept 13; 145(36):19611-19621. doi: 10.1021/jacs.3c03913
Mu Opioid Receptor-Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors. Welsch L, Colantonio E, Frison M, Johnson DA, McClain SP, Mathis V, Banghart MR, Ben Hamida S, Darcq E, Kieffer BL. Biological Psychiatry (2023), June 5:S0006-3223(23)01328-8. doi: 10.1016/j.biopsych.2023.05.019.
In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior. Ma X*, Johnson DA*, He XJ, Layden, AE, McClain SP, Yung JC, Rizzo A, Bonaventura J, Banghart MR. Nature Methods (2023), 20(5): 682-685. doi: 10.1038/s41592-023-01819-w
See also a Research Briefing on this manuscript: Deep-brain photoactivation of an opioid peptide shapes mouse behavior within seconds. Nat Methods (2023). doi: 10.1038/s41592-023-01821-2
The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia. Lubejko ST, Graham RD, Livrizzi G, Schaefer R, Banghart MR, Creed MC. Frontiers in Systems Neuroscience (2022); 16:1044686 doi: 10.3389/fnsys.2022.1044686
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons. He XJ, Patel J, Weiss CE, Ma X, Bloodgood BL, Banghart MR. eLife (2021); 10:e69746 doi: 10.7554/eLife.69746
It’s lights out for presynaptic terminals. He, XJ and Banghart MR. Neuron (2021), 109(11), p1755-57.
Neural basis of opioid-induced respiratory depression and its rescue. Liu, S., Kim, D., Oh, T.G., Pao, G.M.M., Kim, J., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M. and Han, S. Proceedings of the National Academy of Sciences (2021), June 8, 118(23):e2022134118. doi: 10.1073/pnas.2022134118.
___________________________________________________________________________________
Gutnick A, Banghart MR, West ER, Schwarz TL. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nature Cell Biology (2019), May 6. doi: 10.1038/s41556-019-0317-2.
Banghart MR*, He XJ, Sabatini, BL*. A Caged Enkephalin Optimized for Simultaneously Probing Mu and
Delta Opioid Receptors. ACS Chemical Neuroscience (2018), 9(4), 684-690.
Otopalik AG, Sutton AC, Banghart M, Marder E. When complex neuronal structures may not matter. Elife (2017), pii: e23508.
Banghart MR*, Neufeld SQ*, Mulder N, Sabatini BL. Enkephalin disinhibits mu-receptor rich striatal patches via delta opioid receptors. Neuron (2015), 88(6), 1227-39.
Olson J*, Banghart MR*, Sabatini BL, Ellis-Davies GCR. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. Journal of the American Chemical Society (2013), 135(42), 15948-54.
Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Molecular Pharmacology (2013), 84(5), 687-95.
Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron (2012), 73, 249-59.
Tochitsky I*, Banghart MR*, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D. Optical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nature Chemistry (2012), 4(2), 105-11.
Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FME, Stein M, Kramer RH, Trauner D. Tuning photochromic ion channel blockers. ACS Chemical Neuroscience (2011), 2(9), 536-543.
Fortin DL, Dunn TW, Fedorchak A, Allen D, Montpetit R, Banghart MR, Trauner D, Adelman JP, Kramer RH. Optogenetic photochemical control of designer K+ channels in mammalian neurons. Journal of Neurophysiology (2011), 106(1), 488-496.
Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Letters (2010), 10 (1), 250-254.
Banghart MR*, Mourot A*, Fortin DL, Yao JZ, Kramer RH, Trauner D. Photochromic blockers of voltage-gated potassium channels. Angewandte Chemie International Edition (2009), 48 (48), 9097-9101.
Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Photochemical control of endogenous ion channels and cellular excitability. Nature Methods (2008), 5(4), 331-338.
Banghart MR, Volgraf M, Trauner D. Engineering light gated ion channels. Biochemistry (2006), 45(51), 15129-15141.
Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K+ channel and a molecular photoswitch. Journal of Neurophysiology (2006), 96(5), 2792-2796.
Banghart M*, Borges K*, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience (2004), 7(12), 1381-1386.
Ren H, Grady S, Banghart M, Moulthrop JS, Kendrick H, Yardley V, Croft SL, Moyna G. Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European Journal of Medicinal Chemistry (2003), 38(11-12), 949-957.
Miller AK, Banghart MR, Beaudry CM, Suh JM, Trauner D. Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones. Tetrahedron (2003), 59(45), 8919-8930.
Banghart M, Grady S, Ren H, Freyer AI, Moyna G. Assignment of the 1H- and 13C-NMR spectra of purpurogallin derivatives and revision of the structure of purpurogallin tri-methylether using DPFGSE-NOE spectroscopy. Journal of Undergraduate Chemistry Research (2002), 1(2), 77-82.
Non-peer reviewed articles and book chapters
Banghart MR, Trauner D. A 1H NMR assay for quantifying the wavelength sensitivity of azobenzene-based photoswitchable ligands. In Methods in Molecular Biology: Chemical Neurobiology; Banghart MR, Ed.; Springer, New York, 2013; Vol. 995, pp 107.
Volgraf M, Banghart MR, Trauner D. Switchable proteins and channels. In Molecular Switches; Feringa BL, Browne WR, Eds.; Wiley-VCH, New York, 2011; Vol. 1, pp 563.
Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The American Association of Pharmaceutical Scientists Journal (2009) 11(1), 167-177.
Top-down control of the descending pain modulatory system drives placebo analgesia. Livrizzi G, Liao J, Johnson DA, Lubejko ST, Chang-Weinberg J, Dong C, Tian L, Banghart MR. bioRxiv [Preprint]. 2025 Feb 16:2025.02.13.638185. doi: 10.1101/2025.02.13.638185
Mimicking opioid analgesia in cortical pain circuits. James JG, McCall NM, Hsu AI, Oswell CS, Salimando GJ, Mahmood M, Wooldridge LM, Wachira M, Jo A, Sandoval Ortega RA, Wojick JA, Beattie K, Farinas SA, Chehimi SN, Rodrigues A, Ejoh LL, Kimmey BA, Lo E, Azouz G, Vasquez JJ, Banghart MR, Creasy KT, Beier KT, Ramakrishnan C, Crist RC, Reiner BC, Deisseroth K, Yttri EA, Corder G. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591113. doi: 10.1101/2024.04.26.591113.
Articles
A Chemically Stable Photocaged Noradrenaline. Buczynski SA, Li A, Chang-Weinberg J, Nawsheen SS, Banghart MR. ACS Chemical Neuroscience. 2025 Aug 6;16(15):2935-2944. doi: 10.1021/acschemneuro.5c00241
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR†, Banghart MR†, Tian L†. Nature Neuroscience. 2024 Sep;27(9) doi: 10.1038/s41593-024-01697-1.
Convergent inputs to the locus coeruleus from the ventrolateral periaqueductal gray and rostroventromedial medulla shape opioid-mediated descending pain modulation. Lubejko ST, Livrizzi G, Buczynski SA, Patel J, Yung JC, Yaksh TL, Banghart MR. Science Advances (2024), 26 Apr 2024, Vol 10, Issue 17. doi: 10.1126/sciadv.adj958
In vivo photopharmacology with light-activated opioid drugs. McClain SP*, Ma X*, Johnson DA, Johnson CA, Layden AE, Yung JC, Lubejko ST, Livrizzi G, He XJ, Zhou J, Ventriglia E, Rizzo A, Levinstein M, Gomez JL, Bonaventura J, Michaelides M, Banghart MR. Neuron (2023), Dec 20; 111(24):3926-3940.e10. doi: 10.1016/j.neuron.2023.09.017. Epub 2023 Oct 16.
A biomimetic C-terminal extension strategy for photocaging amidated neuropeptides. Layden AE*, Ma X*, Johnson CA, He XJ, Bucynski S, Banghart MR. Journal of the American Chemical Society (2023) Sept 13; 145(36):19611-19621. doi: 10.1021/jacs.3c03913
Mu Opioid Receptor-Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors. Welsch L, Colantonio E, Frison M, Johnson DA, McClain SP, Mathis V, Banghart MR, Ben Hamida S, Darcq E, Kieffer BL. Biological Psychiatry (2023), June 5:S0006-3223(23)01328-8. doi: 10.1016/j.biopsych.2023.05.019.
In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior. Ma X*, Johnson DA*, He XJ, Layden, AE, McClain SP, Yung JC, Rizzo A, Bonaventura J, Banghart MR. Nature Methods (2023), 20(5): 682-685. doi: 10.1038/s41592-023-01819-w
See also a Research Briefing on this manuscript: Deep-brain photoactivation of an opioid peptide shapes mouse behavior within seconds. Nat Methods (2023). doi: 10.1038/s41592-023-01821-2
The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia. Lubejko ST, Graham RD, Livrizzi G, Schaefer R, Banghart MR, Creed MC. Frontiers in Systems Neuroscience (2022); 16:1044686 doi: 10.3389/fnsys.2022.1044686
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons. He XJ, Patel J, Weiss CE, Ma X, Bloodgood BL, Banghart MR. eLife (2021); 10:e69746 doi: 10.7554/eLife.69746
It’s lights out for presynaptic terminals. He, XJ and Banghart MR. Neuron (2021), 109(11), p1755-57.
Neural basis of opioid-induced respiratory depression and its rescue. Liu, S., Kim, D., Oh, T.G., Pao, G.M.M., Kim, J., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M. and Han, S. Proceedings of the National Academy of Sciences (2021), June 8, 118(23):e2022134118. doi: 10.1073/pnas.2022134118.
___________________________________________________________________________________
Gutnick A, Banghart MR, West ER, Schwarz TL. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nature Cell Biology (2019), May 6. doi: 10.1038/s41556-019-0317-2.
Banghart MR*, He XJ, Sabatini, BL*. A Caged Enkephalin Optimized for Simultaneously Probing Mu and
Delta Opioid Receptors. ACS Chemical Neuroscience (2018), 9(4), 684-690.
Otopalik AG, Sutton AC, Banghart M, Marder E. When complex neuronal structures may not matter. Elife (2017), pii: e23508.
Banghart MR*, Neufeld SQ*, Mulder N, Sabatini BL. Enkephalin disinhibits mu-receptor rich striatal patches via delta opioid receptors. Neuron (2015), 88(6), 1227-39.
Olson J*, Banghart MR*, Sabatini BL, Ellis-Davies GCR. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. Journal of the American Chemical Society (2013), 135(42), 15948-54.
Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Molecular Pharmacology (2013), 84(5), 687-95.
Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron (2012), 73, 249-59.
Tochitsky I*, Banghart MR*, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D. Optical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nature Chemistry (2012), 4(2), 105-11.
Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FME, Stein M, Kramer RH, Trauner D. Tuning photochromic ion channel blockers. ACS Chemical Neuroscience (2011), 2(9), 536-543.
Fortin DL, Dunn TW, Fedorchak A, Allen D, Montpetit R, Banghart MR, Trauner D, Adelman JP, Kramer RH. Optogenetic photochemical control of designer K+ channels in mammalian neurons. Journal of Neurophysiology (2011), 106(1), 488-496.
Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Letters (2010), 10 (1), 250-254.
Banghart MR*, Mourot A*, Fortin DL, Yao JZ, Kramer RH, Trauner D. Photochromic blockers of voltage-gated potassium channels. Angewandte Chemie International Edition (2009), 48 (48), 9097-9101.
Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Photochemical control of endogenous ion channels and cellular excitability. Nature Methods (2008), 5(4), 331-338.
Banghart MR, Volgraf M, Trauner D. Engineering light gated ion channels. Biochemistry (2006), 45(51), 15129-15141.
Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K+ channel and a molecular photoswitch. Journal of Neurophysiology (2006), 96(5), 2792-2796.
Banghart M*, Borges K*, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience (2004), 7(12), 1381-1386.
Ren H, Grady S, Banghart M, Moulthrop JS, Kendrick H, Yardley V, Croft SL, Moyna G. Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European Journal of Medicinal Chemistry (2003), 38(11-12), 949-957.
Miller AK, Banghart MR, Beaudry CM, Suh JM, Trauner D. Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones. Tetrahedron (2003), 59(45), 8919-8930.
Banghart M, Grady S, Ren H, Freyer AI, Moyna G. Assignment of the 1H- and 13C-NMR spectra of purpurogallin derivatives and revision of the structure of purpurogallin tri-methylether using DPFGSE-NOE spectroscopy. Journal of Undergraduate Chemistry Research (2002), 1(2), 77-82.
Non-peer reviewed articles and book chapters
Banghart MR, Trauner D. A 1H NMR assay for quantifying the wavelength sensitivity of azobenzene-based photoswitchable ligands. In Methods in Molecular Biology: Chemical Neurobiology; Banghart MR, Ed.; Springer, New York, 2013; Vol. 995, pp 107.
Volgraf M, Banghart MR, Trauner D. Switchable proteins and channels. In Molecular Switches; Feringa BL, Browne WR, Eds.; Wiley-VCH, New York, 2011; Vol. 1, pp 563.
Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The American Association of Pharmaceutical Scientists Journal (2009) 11(1), 167-177.